Effects of Vitamin D3 and Meso-Zeaxanthin on Human Retinal Pigmented Epithelial Cells in Three Integrated in vitro Paradigms of Age-Related Macular Degeneration

Effects of Vitamin D3 and Meso-Zeaxanthin on Human Retinal Pigmented Epithelial Cells in Three Integrated in vitro Paradigms of Age-Related Macular Degeneration

Age-related macular degeneration (AMD) is a degenerative retinal disease and one of major causes of irreversible vision loss. AMD has been linked to several pathological factors, such as oxidative stress and inflammation. Moreover, Aβ (1–42) oligomers have been found in drusen, the extracellular dep...

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Bibliographic Details
Main Authors: Francesca Lazzara, Federica Conti, Chiara Bianca Maria Platania, Chiara M. Eandi, Filippo Drago, Claudio Bucolo
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Pharmacology
Subjects:
1,25(OH)2D3
meso-zeaxanthin
amyloid beta
inflammation
oxidative stress
cytokines
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.778165/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.778165/full

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