Cyclooxygenase-2 Pathway Correlates with VEGF Expression in Head and Neck Cancer. Implications for Tumor Angiogenesis and Metastasis

Cyclooxygenase-2 Pathway Correlates with VEGF Expression in Head and Neck Cancer. Implications for Tumor Angiogenesis and Metastasis

We evaluated the role of COX-2 pathway in 35 head and neck cancers (HNCs) by analyzing COX-2 expression and prostaglandin E2 (PGE2) production in relation to tumor angiogenesis and lymph node metastasis. COX-2 activity was also correlated to vascular endothelial growth factor (VEGF) mRNA and protein...

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Bibliographic Details
Main Authors: Oreste Gallo, Alessandro Franchi, Lucia Magnelli, Iacopo Sardi, Alfredo Vannacci, Vieri Boddit, Vincenzo Chiarugi, Emanuela Masini
Format: Article
Language:English
Published: Elsevier 2001-01-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
head and neck cancer
COX-2
VEGF
angiogenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558601800166

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http://www.sciencedirect.com/science/article/pii/S1476558601800166

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