Intracerebral but Not Peripheral Infection of Live <i>Porphyromonas gingivalis</i> Exacerbates Alzheimer’s Disease Like Amyloid Pathology in APP-TgCRND8 Mice

The impact of oral microbial dysbiosis on Alzheimer’s disease (AD) remains controversial. Building off recent studies reporting that various microbes might directly seed or promote amyloid β (Aβ) deposition, we evaluated the effects of periodontal bacteria (<i>Porphyromonas gingivalis, Trepone...

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Bibliographic Details
Main Authors: Chairmandurai Aravindraja, Ravi Sakthivel, Xuefei Liu, Marshall Goodwin, Patnam Veena, Valentina Godovikova, J. Christopher Fenno, Yona Levites, Todd E. Golde, Lakshmyya Kesavalu
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:International Journal of Molecular Sciences
Subjects:
Online Access:https://www.mdpi.com/1422-0067/23/6/3328