High-dose dexamethasone regulates microglial polarization via the GR/JAK1/STAT3 signaling pathway after traumatic brain injury

High-dose dexamethasone regulates microglial polarization via the GR/JAK1/STAT3 signaling pathway after traumatic brain injury

Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury, the fundamental regulatory and functional mechanisms remain insufficiently understood. As potent anti-inflammatory agents, the use of glucocorticoids in traumatic brain injury is still...

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Bibliographic Details
Main Authors: Mengshi Yang, Miao Bai, Yuan Zhuang, Shenghua Lu, Qianqian Ge, Hao Li, Yu Deng, Hongbin Wu, Xiaojian Xu, Fei Niu, Xinlong Dong, Bin Zhang, Baiyun Liu
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2025-09-01
Series:Neural Regeneration Research
Subjects:
apoptosis
bv2 microglia
dexamethasone
glucocorticoid receptor
glucocorticoids
innate immune system
microglial polarization
neuroinflammation
primary microglia
traumatic brain injury
Online Access:https://journals.lww.com/10.4103/NRR.NRR-D-23-01772

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https://journals.lww.com/10.4103/NRR.NRR-D-23-01772

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