Synthesis and Biological Evaluation of Cyclobutane-Based β3 Integrin Antagonists: A Novel Approach to Targeting Integrins for Cancer Therapy

Synthesis and Biological Evaluation of Cyclobutane-Based β3 Integrin Antagonists: A Novel Approach to Targeting Integrins for Cancer Therapy

The Arg-Gly-Asp (RGD)-binding family of integrin receptors, and notably the β3 subfamily, are key to multiple physiological processes involved in tissue development, cancer proliferation, and metastatic dissemination. While there is compelling preclinical evidence that both αvβ3 and αIIbβ3 are impor...

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Bibliographic Details
Main Authors: Mark Sutherland, Andrew Gordon, Fatemah O. F. O. Al-Shammari, Adam Throup, Amy Cilia La Corte, Helen Philippou, Steven D. Shnyder, Laurence H. Patterson, Helen M. Sheldrake
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Cancers
Subjects:
integrin αvβ3
integrin αIIbβ3
metastasis
RGD mimetic
cyclobutane
drug discovery
Online Access:https://www.mdpi.com/2072-6694/15/16/4023

Internet

https://www.mdpi.com/2072-6694/15/16/4023

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