The role of Smarcad1 in retroviral repression in mouse embryonic stem cells

The role of Smarcad1 in retroviral repression in mouse embryonic stem cells

Abstract Background Moloney murine leukemia virus (MLV) replication is suppressed in mouse embryonic stem cells (ESCs) by the Trim28-SETDB1 complex. The chromatin remodeler Smarcad1 interacts with Trim28 and was suggested to allow the deposition of the histone variant H3.3. However, the role of Trim...

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Bibliographic Details
Main Authors: Igor Bren, Ayellet Tal, Carmit Strauss, Sharon Schlesinger
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Mobile DNA
Subjects:
H3.3
Smarcad1
Trim28
Retrovirus
Embryonic stem cells
Epigenetic silencing
Online Access:https://doi.org/10.1186/s13100-024-00314-z

Internet

https://doi.org/10.1186/s13100-024-00314-z

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