Metformin pretreatment rescues olfactory memory associated with subependymal zone neurogenesis in a juvenile model of cranial irradiation

Metformin pretreatment rescues olfactory memory associated with subependymal zone neurogenesis in a juvenile model of cranial irradiation

Summary: Cranial irradiation (IR) is an effective adjuvant therapy in the treatment of childhood brain tumors but results in long-lasting cognitive deficits associated with impaired neurogenesis, as evidenced in rodent models. Metformin has been shown to expand the endogenous neural stem cell (NSC)...

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Bibliographic Details
Main Authors: Daniel Derkach, Tarlan Kehtari, Matthew Renaud, Mohsen Heidari, Nishanth Lakshman, Cindi M. Morshead
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Cell Reports Medicine
Subjects:
cranial irradiation
metformin
neural stem cells
neurogenesis
subependymal zone
olfaction
Online Access:http://www.sciencedirect.com/science/article/pii/S2666379121000471

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http://www.sciencedirect.com/science/article/pii/S2666379121000471

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