Fatty acids negatively regulate platelet function through formation of noncanonical 15‐lipoxygenase‐derived eicosanoids

Fatty acids negatively regulate platelet function through formation of noncanonical 15‐lipoxygenase‐derived eicosanoids

Abstract The antiplatelet effect of polyunsaturated fatty acids is primarily attributed to its metabolism to bioactive metabolites by oxygenases, such as lipoxygenases (LOX). Platelets have demonstrated the ability to generate 15‐LOX‐derived metabolites (15‐oxylipins); however, whether 15‐LOX is in...

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Bibliographic Details
Main Authors: Adriana Yamaguchi, Christopher vanHoorebeke, Benjamin E. Tourdot, Steven C. Perry, Grace Lee, Nicole Rhoads, Andrew Rickenberg, Abigail R. Green, James Sorrentino, Jennifer Yeung, J. Cody Freedman, Theodore R. Holman, Michael Holinstat
Format: Article
Language:English
Published: Wiley 2023-02-01
Series:Pharmacology Research & Perspectives
Subjects:
15‐lipoxygenase
lipoxygenase
platelet
Online Access:https://doi.org/10.1002/prp2.1056

Internet

https://doi.org/10.1002/prp2.1056

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