Synthesis of Diversified Pyrazolo[3,4-<i>b</i>]pyridine Frameworks from 5-Aminopyrazoles and Alkynyl Aldehydes via Switchable C≡C Bond Activation Approaches

Synthesis of Diversified Pyrazolo[3,4-<i>b</i>]pyridine Frameworks from 5-Aminopyrazoles and Alkynyl Aldehydes via Switchable C≡C Bond Activation Approaches

A cascade <i>6-endo-dig</i> cyclization reaction was developed for the switchable synthesis of halogen and non-halogen-functionalized pyrazolo[3,4-<i>b</i>]pyridines from 5-aminopyrazoles and alkynyl aldehydes via C≡C bond activation with silver, iodine, or NBS. In addition t...

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Bibliographic Details
Main Authors: Xiao-Yu Miao, Yong-Ji Hu, Fu-Rao Liu, Yuan-Yuan Sun, Die Sun, An-Xin Wu, Yan-Ping Zhu
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Molecules
Subjects:
pyrazolo[3,4-<i>b</i>]pyridine
alkyne activation
regional selectivity
<i>6-endo-dig</i> cyclization
Online Access:https://www.mdpi.com/1420-3049/27/19/6381

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https://www.mdpi.com/1420-3049/27/19/6381

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