Hedysari Radix Praeparata Cum Melle repairs impaired intestinal barrier function and alleviates colitis-associated colorectal cancer via remodeling gut microbiota and metabolism
Hedysari Radix Praeparata Cum Melle (HR) has a potential to decrease the risk of chronic colorectal inflammation developing to colorectal cancer. Our study found that HR attenuated the pathological state, improved survival rate, diminished K-Ras, IL-1β, IL-6 and TNF-α levels, and increased the level...
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Elsevier
2023-09-01
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Series: | Journal of Functional Foods |
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Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464623003481 |
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author | Yugui Zhang Yuefeng Li Tiantian Bian Yujing Sun Zhuanhong Zhang Ting Liu Feiyun Gao Yanjun Wang Rui Cao Erdan Xin Xingke Yan |
author_facet | Yugui Zhang Yuefeng Li Tiantian Bian Yujing Sun Zhuanhong Zhang Ting Liu Feiyun Gao Yanjun Wang Rui Cao Erdan Xin Xingke Yan |
author_sort | Yugui Zhang |
collection | DOAJ |
description | Hedysari Radix Praeparata Cum Melle (HR) has a potential to decrease the risk of chronic colorectal inflammation developing to colorectal cancer. Our study found that HR attenuated the pathological state, improved survival rate, diminished K-Ras, IL-1β, IL-6 and TNF-α levels, and increased the levels of the intestinal barrier function proteins including claudin-1, E-cadherin and mucin-2 in colitis-associated colorectal cancer (CAC) mice. Moreover, HR maintains intestinal flora homeostasis and fecal metabolic profiling through balancing the abundances of bacteroides prevotellaceae_UCG-001, staphylococcus, turicibacter, and rikenella to further regulates the galactose metabolism. The spearman correlation analysis showed that the intestinal barrier function proteins, gut microbiota and differential metabolism were significantly correlated with each other. This study confirmed a potential mechanism that HR alleviates CAC by diminishing symptoms and the inflammation, thereby improving the function of intestinal barrier and preserving intestinal flora homeostasis and fecal metabolic profiling. |
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id | doaj.art-59a810cb6ab4416cab5b1ed6bcc97809 |
institution | Directory Open Access Journal |
issn | 1756-4646 |
language | English |
last_indexed | 2024-03-12T01:38:07Z |
publishDate | 2023-09-01 |
publisher | Elsevier |
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series | Journal of Functional Foods |
spelling | doaj.art-59a810cb6ab4416cab5b1ed6bcc978092023-09-11T04:16:53ZengElsevierJournal of Functional Foods1756-46462023-09-01108105748Hedysari Radix Praeparata Cum Melle repairs impaired intestinal barrier function and alleviates colitis-associated colorectal cancer via remodeling gut microbiota and metabolismYugui Zhang0Yuefeng Li1Tiantian Bian2Yujing Sun3Zhuanhong Zhang4Ting Liu5Feiyun Gao6Yanjun Wang7Rui Cao8Erdan Xin9Xingke Yan10College of Pharmacy, Gansu University of Chinese Medicine, Lanzhou 730000, PR China; Key Laboratory of Standard and Quality of Chinese Medicine Research of Gansu, Engineering Research Center of Chinese Medicine Pharmaceutical Process of Gansu, Gansu University of Chinese Medicine, Lanzhou 730000, PR ChinaCollege of Pharmacy, Gansu University of Chinese Medicine, Lanzhou 730000, PR China; Key Laboratory of Standard and Quality of Chinese Medicine Research of Gansu, Engineering Research Center of Chinese Medicine Pharmaceutical Process of Gansu, Gansu University of Chinese Medicine, Lanzhou 730000, PR China; Scientific Research and Experimental Center, Gansu University of Chinese Medicine, Lanzhou, 730000, PR ChinaCollege of Pharmacy, Gansu University of Chinese Medicine, Lanzhou 730000, PR China; Key Laboratory of Standard and Quality of Chinese Medicine Research of Gansu, Engineering Research Center of Chinese Medicine Pharmaceutical Process of Gansu, Gansu University of Chinese Medicine, Lanzhou 730000, PR ChinaCollege of Pharmacy, Gansu University of Chinese Medicine, Lanzhou 730000, PR China; Key Laboratory of Standard and Quality of Chinese Medicine Research of Gansu, Engineering Research Center of Chinese Medicine Pharmaceutical Process of Gansu, Gansu University of Chinese Medicine, Lanzhou 730000, PR ChinaCollege of Pharmacy, Gansu University of Chinese Medicine, Lanzhou 730000, PR China; Key Laboratory of Standard and Quality of Chinese Medicine Research of Gansu, Engineering Research Center of Chinese Medicine Pharmaceutical Process of Gansu, Gansu University of Chinese Medicine, Lanzhou 730000, PR ChinaCollege of Pharmacy, Gansu University of Chinese Medicine, Lanzhou 730000, PR China; Key Laboratory of Standard and Quality of Chinese Medicine Research of Gansu, Engineering Research Center of Chinese Medicine Pharmaceutical Process of Gansu, Gansu University of Chinese Medicine, Lanzhou 730000, PR ChinaCollege of Pharmacy, Gansu University of Chinese Medicine, Lanzhou 730000, PR China; Key Laboratory of Standard and Quality of Chinese Medicine Research of Gansu, Engineering Research Center of Chinese Medicine Pharmaceutical Process of Gansu, Gansu University of Chinese Medicine, Lanzhou 730000, PR ChinaCollege of Pharmacy, Gansu University of Chinese Medicine, Lanzhou 730000, PR China; Key Laboratory of Standard and Quality of Chinese Medicine Research of Gansu, Engineering Research Center of Chinese Medicine Pharmaceutical Process of Gansu, Gansu University of Chinese Medicine, Lanzhou 730000, PR ChinaCollege of Pharmacy, Gansu University of Chinese Medicine, Lanzhou 730000, PR China; Key Laboratory of Standard and Quality of Chinese Medicine Research of Gansu, Engineering Research Center of Chinese Medicine Pharmaceutical Process of Gansu, Gansu University of Chinese Medicine, Lanzhou 730000, PR ChinaCollege of Pharmacy, Gansu University of Chinese Medicine, Lanzhou 730000, PR China; Key Laboratory of Standard and Quality of Chinese Medicine Research of Gansu, Engineering Research Center of Chinese Medicine Pharmaceutical Process of Gansu, Gansu University of Chinese Medicine, Lanzhou 730000, PR ChinaCollege of Acupuncture-Moxibustion and Tuina, Gansu University of Chinese Medicine, Lanzhou 730000, PR China; Corresponding author at: 35 Dingxi East Road, Chengguan District, Lanzhou City, Gansu Province, China.Hedysari Radix Praeparata Cum Melle (HR) has a potential to decrease the risk of chronic colorectal inflammation developing to colorectal cancer. Our study found that HR attenuated the pathological state, improved survival rate, diminished K-Ras, IL-1β, IL-6 and TNF-α levels, and increased the levels of the intestinal barrier function proteins including claudin-1, E-cadherin and mucin-2 in colitis-associated colorectal cancer (CAC) mice. Moreover, HR maintains intestinal flora homeostasis and fecal metabolic profiling through balancing the abundances of bacteroides prevotellaceae_UCG-001, staphylococcus, turicibacter, and rikenella to further regulates the galactose metabolism. The spearman correlation analysis showed that the intestinal barrier function proteins, gut microbiota and differential metabolism were significantly correlated with each other. This study confirmed a potential mechanism that HR alleviates CAC by diminishing symptoms and the inflammation, thereby improving the function of intestinal barrier and preserving intestinal flora homeostasis and fecal metabolic profiling.http://www.sciencedirect.com/science/article/pii/S1756464623003481Hedysari Radix Praeparata Cum MelleColitis-associated colorectal cancerGut microbiotaMetabolitesIntestinal barrier functionMechanism |
spellingShingle | Yugui Zhang Yuefeng Li Tiantian Bian Yujing Sun Zhuanhong Zhang Ting Liu Feiyun Gao Yanjun Wang Rui Cao Erdan Xin Xingke Yan Hedysari Radix Praeparata Cum Melle repairs impaired intestinal barrier function and alleviates colitis-associated colorectal cancer via remodeling gut microbiota and metabolism Journal of Functional Foods Hedysari Radix Praeparata Cum Melle Colitis-associated colorectal cancer Gut microbiota Metabolites Intestinal barrier function Mechanism |
title | Hedysari Radix Praeparata Cum Melle repairs impaired intestinal barrier function and alleviates colitis-associated colorectal cancer via remodeling gut microbiota and metabolism |
title_full | Hedysari Radix Praeparata Cum Melle repairs impaired intestinal barrier function and alleviates colitis-associated colorectal cancer via remodeling gut microbiota and metabolism |
title_fullStr | Hedysari Radix Praeparata Cum Melle repairs impaired intestinal barrier function and alleviates colitis-associated colorectal cancer via remodeling gut microbiota and metabolism |
title_full_unstemmed | Hedysari Radix Praeparata Cum Melle repairs impaired intestinal barrier function and alleviates colitis-associated colorectal cancer via remodeling gut microbiota and metabolism |
title_short | Hedysari Radix Praeparata Cum Melle repairs impaired intestinal barrier function and alleviates colitis-associated colorectal cancer via remodeling gut microbiota and metabolism |
title_sort | hedysari radix praeparata cum melle repairs impaired intestinal barrier function and alleviates colitis associated colorectal cancer via remodeling gut microbiota and metabolism |
topic | Hedysari Radix Praeparata Cum Melle Colitis-associated colorectal cancer Gut microbiota Metabolites Intestinal barrier function Mechanism |
url | http://www.sciencedirect.com/science/article/pii/S1756464623003481 |
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