Continous, non-invasive monitoring of oxygen consumption in a parallelized microfluidic in vitro system provides novel insight into the response to nutrients and drugs of primary human hepatocytes

Continous, non-invasive monitoring of oxygen consumption in a parallelized microfluidic in vitro system provides novel insight into the response to nutrients and drugs of primary human hepatocytes

Oxygen plays a fundamental role in cellular energy metabolism, differentiation and cell biology in general. Consequently, in vitro oxygen sensing can be used to assess cell vitality and detect specific mechanisms of toxicity. In 2D in vitro models currently used, the oxygen supply provided by diffus...

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Bibliographic Details
Main Authors: Marius Busche, Dominik Rabl, Jan Fischer, Christian Schmees, Torsten Mayr, Rolf Gebhardt, Martin Stelzle
Format: Article
Language:English
Published: IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund 2022-01-01
Series:EXCLI Journal : Experimental and Clinical Sciences
Subjects:
liver
organ-on-chip
perfusion
oxygen
sensors
in vitro
model
toxicity
metabolism
Online Access:https://www.excli.de/index.php/excli/article/view/4351

Internet

https://www.excli.de/index.php/excli/article/view/4351

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