CYP17A1 Maintains the Survival of Glioblastomas by Regulating SAR1-Mediated Endoplasmic Reticulum Health and Redox Homeostasis

CYP17A1 Maintains the Survival of Glioblastomas by Regulating SAR1-Mediated Endoplasmic Reticulum Health and Redox Homeostasis

Cytochrome P450 (CYP) 17A1 is an important steroidogenic enzyme harboring 17α-hydroxylase and performing 17,20 lyase activities in multiple steps of steroid hormone synthesis, including dehydroepiandrosterone (DHEA) biosynthesis. Previously, we showed that CYP17A1-mediated DHEA production c...

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Bibliographic Details
Main Authors: Hong-Yi Lin, Chiung-Yuan Ko, Tzu-Jen Kao, Wen-Bin Yang, Yu-Ting Tsai, Jian-Ying Chuang, Siou-Lian Hu, Pei-Yu Yang, Wei-Lun Lo, Tsung-I Hsu
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Cancers
Subjects:
CYP17A1
glioblastoma
abiraterone
SAR1
Online Access:https://www.mdpi.com/2072-6694/11/9/1378

Internet

https://www.mdpi.com/2072-6694/11/9/1378

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