Modulation of SIRT6 activity acts as an emerging therapeutic implication for pathological disorders in the skeletal system

Modulation of SIRT6 activity acts as an emerging therapeutic implication for pathological disorders in the skeletal system

The skeletal system is a dynamically balanced system, which undergoes continuous bone resorption and formation to maintain bone matrix homeostasis. As an important ADP-ribosylase and NAD+-dependent deacylase, SIRT6 (SIR2-like protein 6) is widely expressed on various kinds of bone cells, such as cho...

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Bibliographic Details
Main Authors: Zicai Dong, Chuan Yang, Jiulin Tan, Ce Dou, Yueqi Chen
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2023-05-01
Series:Genes and Diseases
Subjects:
Intervertebral disc degeneration (IDD)
Osteoarthritis (OA)
Osteoporosis (OP)
Rheumatoid arthritis (RA)
SIRT6 (SIR2-Like protein 6)
SIRT6 activator
Online Access:http://www.sciencedirect.com/science/article/pii/S2352304222000186

Internet

http://www.sciencedirect.com/science/article/pii/S2352304222000186

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