Impaired dynamic interaction of axonal endoplasmic reticulum and ribosomes contributes to defective stimulus–response in spinal muscular atrophy

Impaired dynamic interaction of axonal endoplasmic reticulum and ribosomes contributes to defective stimulus–response in spinal muscular atrophy

Abstract Background Axonal degeneration and defects in neuromuscular neurotransmission represent a pathological hallmark in spinal muscular atrophy (SMA) and other forms of motoneuron disease. These pathological changes do not only base on altered axonal and presynaptic architecture, but also on alt...

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Bibliographic Details
Main Authors: Chunchu Deng, Sebastian Reinhard, Luisa Hennlein, Janna Eilts, Stefan Sachs, Sören Doose, Sibylle Jablonka, Markus Sauer, Mehri Moradi, Michael Sendtner
Format: Article
Language:English
Published: BMC 2022-06-01
Series:Translational Neurodegeneration
Subjects:
Spinal muscular atrophy
Presynaptic ER dynamics
Dynamics of ribosomal assembly
BDNF stimulation
Online Access:https://doi.org/10.1186/s40035-022-00304-2

Internet

https://doi.org/10.1186/s40035-022-00304-2

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