Differential toxicity and localization of arginine-rich C9ORF72 dipeptide repeat proteins depend on de-clustering of positive charges

Differential toxicity and localization of arginine-rich C9ORF72 dipeptide repeat proteins depend on de-clustering of positive charges

Summary: Arginine-rich dipeptide repeat proteins (R-DPRs), poly(PR) and poly(GR), translated from the hexanucleotide repeat expansion in the amyotrophic lateral sclerosis (ALS)-causative C9ORF72 gene, contribute significantly to pathogenesis of ALS. Although both R-DPRs share many similarities, ther...

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Bibliographic Details
Main Authors: Tamami Miyagi, Koji Ueda, Masahiro Sugimoto, Takuya Yagi, Daisuke Ito, Rio Yamazaki, Satoshi Narumi, Yuhei Hayamizu, Hiroshi Uji-i, Masahiko Kuroda, Kohsuke Kanekura
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:iScience
Subjects:
Molecular biology
Neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223010349

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http://www.sciencedirect.com/science/article/pii/S2589004223010349

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