Enzymatic Desymmetrisation of Prochiral <i>meso</i>-1,2-Disubstituted-1,2-Diaminoethane for the Synthesis of Key Enantioenriched (−)-Nutlin-3 Precursor

Enzymatic Desymmetrisation of Prochiral <i>meso</i>-1,2-Disubstituted-1,2-Diaminoethane for the Synthesis of Key Enantioenriched (−)-Nutlin-3 Precursor

Herein we present the biocatalysed preparation of a mono-<i>N</i>-carbamate-protected precursor of antitumoral Nutlin-3a through enantioselective alkoxycarbonylation of <i>meso</i>-1,2-disubstituted-1,2-diaminoethane using enzyme lipases and dialkyl carbonates as acylating ag...

Full description

Bibliographic Details
Main Authors: Virginia Cristofori, Davide Illuminati, Chiara Bisquoli, Martina Catani, Greta Compagnin, Giulia Turrin, Claudio Trapella, Anna Fantinati
Format: Article
Language:English
Published: MDPI AG 2024-07-01
Series:Molecules
Subjects:
biocatalysis
Nutlin-3a
desymmetrisation
vicinal <i>meso</i>-diamines
Online Access:https://www.mdpi.com/1420-3049/29/14/3267

Internet

https://www.mdpi.com/1420-3049/29/14/3267

Similar Items