Single-cell analysis reveals X upregulation is not global in pre-gastrulation embryos

Summary: In mammals, transcriptional inactivation of one X chromosome in female compensates for the dosage of X-linked gene expression between the sexes. Additionally, it is believed that the upregulation of active X chromosome in male and female balances the dosage of X-linked gene expression relat...

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Bibliographic Details
Main Authors: Hemant Chandru Naik, Kishore Hari, Deepshikha Chandel, Mohit Kumar Jolly, Srimonta Gayen
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222007362