Soluble Epoxide Hydrolase Blockade after Stroke Onset Protects Normal but Not Diabetic Mice

Soluble Epoxide Hydrolase Blockade after Stroke Onset Protects Normal but Not Diabetic Mice

Soluble epoxide hydrolase (sEH) is abundant in the brain, is upregulated in type 2 diabetes mellitus (DM2), and is possible mediator of ischemic injury via the breakdown of neuroprotective epoxyeicosatrienoic acids (EETs). Prophylactic, pre-ischemic sEH blockade with 4-[[<i>trans</i>-4-[...

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Bibliographic Details
Main Authors: Catherine M. Davis, Wenri H. Zhang, Elyse M. Allen, Thierno M. Bah, Robert E. Shangraw, Nabil J. Alkayed
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
type 2 diabetes mellitus
sEH
stroke
Online Access:https://www.mdpi.com/1422-0067/22/11/5419

Internet

https://www.mdpi.com/1422-0067/22/11/5419

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