DNA hypomethylator phenotype reprograms glutamatergic network in receptor tyrosine kinase gene-mutated glioblastoma

DNA hypomethylator phenotype reprograms glutamatergic network in receptor tyrosine kinase gene-mutated glioblastoma

Abstract DNA methylation is crucial for chromatin structure and gene expression and its aberrancies, including the global “hypomethylator phenotype”, are associated with cancer. Here we show that an underlying mechanism for this phenotype in the large proportion of the highly lethal brain tumor glio...

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Bibliographic Details
Main Authors: Mio Harachi, Kenta Masui, Erika Shimizu, Kumiko Murakami, Hiromi Onizuka, Yoshihiro Muragaki, Takakazu Kawamata, Hisako Nakayama, Mariko Miyata, Takashi Komori, Webster K. Cavenee, Paul S. Mischel, Atsushi Kurata, Noriyuki Shibata
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Acta Neuropathologica Communications
Subjects:
DNA hypomethylation
mTORC2
DNMT3A
EZH2
Glutamate metabolism
Glioblastoma
Online Access:https://doi.org/10.1186/s40478-024-01750-x

Internet

https://doi.org/10.1186/s40478-024-01750-x

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