Structure of full-length cobalamin-dependent methionine synthase and cofactor loading captured in crystallo
Abstract Cobalamin-dependent methionine synthase (MS) is a key enzyme in methionine and folate one-carbon metabolism. MS is a large multi-domain protein capable of binding and activating three substrates: homocysteine, folate, and S-adenosylmethionine for methylation. Achieving three chemically dist...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2023-10-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-023-42037-4 |