NORAD01-GRECCAR16 multicenter phase III non-inferiority randomized trial comparing preoperative modified FOLFIRINOX without irradiation to radiochemotherapy for resectable locally advanced rectal cancer (intergroup FRENCH-GRECCAR- PRODIGE trial)

NORAD01-GRECCAR16 multicenter phase III non-inferiority randomized trial comparing preoperative modified FOLFIRINOX without irradiation to radiochemotherapy for resectable locally advanced rectal cancer (intergroup FRENCH-GRECCAR- PRODIGE trial)

Abstract Background Preoperative radiochemotherapy (RCT) is recommended in France prior to total mesorectal excision in patients with mid or low locally advanced rectal cancer (LARC) (cT3/T4 and/or N+) because it has been shown to improve local control. Preoperative RCT has also disadvantages includ...

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Bibliographic Details
Main Authors: Antoine Brouquet, Jean-Baptiste Bachet, Florence Huguet, Mehdi Karoui, Pascal Artru, Charles Sabbagh, Jérémie H. Lefèvre, Dewi Vernerey, Christophe Mariette, Eric Vicaut, Stephane Benoist, on behalf the FRENCH , GRECCAR, PRODIGE study groups
Format: Article
Language:English
Published: BMC 2020-05-01
Series:BMC Cancer
Subjects:
Locally advanced rectal cancer
Circumferential resection margin
Preoperative chemotherapy
Preoperative radiochemotherapy
Quality of life
Functional result
Online Access:http://link.springer.com/article/10.1186/s12885-020-06968-1

Internet

http://link.springer.com/article/10.1186/s12885-020-06968-1

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