A genomic approach to study Down syndrome and cancer inverse comorbidity: Untangling the Chromosome 21

A genomic approach to study Down syndrome and cancer inverse comorbidity: Untangling the Chromosome 21

Down syndrome (DS), one of the most common birth defects and the most widespread genetic cause of intellectual disabilities, is caused by extra genetic material on chromosome 21 (HSA21). The increased genomic dosage of trisomy 21 is thought to be responsible for the distinct DS phenotypes, including...

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Bibliographic Details
Main Authors: Jaume eForés-Martos, Raimundo eCervera-Vidal, Enrique Alejandro Chirivella Perez, Alberto eRamos-Jarero, Joan eCliment
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-02-01
Series:Frontiers in Physiology
Subjects:
Down Syndrome
Cancer genomics
RCAN1
21p11
Trisomy HSA21
Inverse comorbidity
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00010/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00010/full

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