Molecular Dynamics Simulations Reveal the Conformational Transition of GH33 Sialidases

Molecular Dynamics Simulations Reveal the Conformational Transition of GH33 Sialidases

Sialidases are increasingly used in the production of sialyloligosaccharides, a significant component of human milk oligosaccharides. Elucidating the catalytic mechanism of sialidases is critical for the rational design of better biocatalysts, thereby facilitating the industrial production of sialyl...

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Bibliographic Details
Main Authors: Xueting Cao, Xiao Yang, Min Xiao, Xukai Jiang
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:International Journal of Molecular Sciences
Subjects:
sialidase
GH33
HMOs
molecular dynamics simulations
catalytic mechanisms
protein engineering
Online Access:https://www.mdpi.com/1422-0067/24/7/6830

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https://www.mdpi.com/1422-0067/24/7/6830

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