Derepressing of STAT3 and USP7 contributes to resistance of DLBCL to EZH2 inhibition

Diffuse large B-cell lymphoma is the most common subtype of lymphoma, representing ∼25 % of non-Hodgkin lymphoid malignancies. EZH2 is highly expressed in Diffuse large B-cell lymphoma and ∼22 % of patients contain EZH2 mutations. EZH2 have been studied as a potential therapeutic target for a decade...

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Bibliographic Details
Main Authors: Chenyun He, Wenbin Zhou, Xiaoxia Jin, Haining Zhou
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:Heliyon
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023078581