Structural basis of a bi-functional malonyl-CoA reductase (MCR) from the photosynthetic green non-sulfur bacterium Roseiflexus castenholzii

Structural basis of a bi-functional malonyl-CoA reductase (MCR) from the photosynthetic green non-sulfur bacterium Roseiflexus castenholzii

ABSTRACT Malonyl-CoA reductase (MCR) is a NADPH-dependent bi-functional enzyme that performs alcohol dehydrogenase and aldehyde dehydrogenase (CoA-acylating) activities in the N- and C-terminal fragments, respectively. It catalyzes the two-step reduction of malonyl-CoA to 3-hydroxypropionate (3-HP),...

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Bibliographic Details
Main Authors: Xin Zhang, Jiyu Xin, Zhiguo Wang, Wenping Wu, Yutong Liu, Zhenzhen Min, Yueyong Xin, Bing Liu, Jun He, Xingwei Zhang, Xiaoling Xu
Format: Article
Language:English
Published: American Society for Microbiology 2023-08-01
Series:mBio
Subjects:
malonyl-CoA reductase
short-chain dehydrogenase/reductase
Roseiflexus castenholzii
bi-functional enzyme
3-hydroxypropionate
Online Access:https://journals.asm.org/doi/10.1128/mbio.03233-22

Internet

https://journals.asm.org/doi/10.1128/mbio.03233-22

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