Combination with Toll-like receptor 4 (TLR4) agonist reverses GITR agonism mediated M2 polarization of macrophage in Hepatocellular carcinoma

Combination with Toll-like receptor 4 (TLR4) agonist reverses GITR agonism mediated M2 polarization of macrophage in Hepatocellular carcinoma

The glucocorticoid-induced tumor necrosis factor receptor (GITR) agonistic antibody (DTA-1) has been proved to elicit robust immune response in various kinds of tumors. However, only a few of the HCC patients could benefit from it, and the mechanism of DTA-1 resistance remains unknown. Here, we meas...

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Bibliographic Details
Main Authors: Caixu Pan, Qinchuan Wu, Shuai Wang, Zhibin Mei, Lele Zhang, Xingxing Gao, Junjie Qian, Zhentian Xu, Ke Zhang, Rong Su, Danjing Guo, Lin Zhou, Shusen Zheng
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:OncoImmunology
Subjects:
GITR
regulatory T cells
Th2 response
M2 polarization of macrophage
Toll-like receptor 4
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2022.2073010

Internet

https://www.tandfonline.com/doi/10.1080/2162402X.2022.2073010

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