An improved total synthesis of tunicamycin V

The tunicamycins are important biochemical tools to study N-linked glycosylation and protein misfolding in cancer biochemistry fields. We reported a convergent synthesis of tunicamycin V with 21% overall yield from D-galactal. We have further optimized our original synthetic scheme by increasing the...

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Bibliographic Details
Main Authors: Katsuhiko Mitachi, David Mingle, Michio Kurosu
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:MethodsX
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2215016123000973