The testicular and epididymal expression profile of PLCζ in mouse and human does not support its role as a sperm-borne oocyte activating factor.

Phospholipase C zeta (PLCζ) is a candidate sperm-borne oocyte activating factor (SOAF) which has recently received attention as a potential biomarker of human male infertility. However, important SOAF attributes of PLCζ, including its developmental expression in mammalian spermiogenesis, its compart...

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Bibliographic Details
Main Authors: Mahmoud Aarabi, Yang Yu, Wei Xu, Man Y Tse, Stephen C Pang, Young-Joo Yi, Peter Sutovsky, Richard Oko
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3299792?pdf=render