Therapeutic Potential of a Small-Molecule STAT3 Inhibitor in a Mouse Model of Colitis

Therapeutic Potential of a Small-Molecule STAT3 Inhibitor in a Mouse Model of Colitis

Background and Aims: Inflammatory bowel disease (IBD) predisposes to colorectal cancer (CRC). In the current studies, we used the dextran sodium sulfate (DSS) murine model of colitis, which is widely used in preclinical studies, to determine the contribution of STAT3 to IBD. STAT3 has two isoforms:...

Full description

Bibliographic Details
Main Authors: Prema Robinson, Kelsey Montoya, Emily Magness, Emma Rodriguez, Viviana Villalobos, Nikita Engineer, Peng Yang, Uddalak Bharadwaj, Thomas Kris Eckols, David John Tweardy
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Cancers
Subjects:
STAT3
inflammatory bowel disease
ulcerative colitis
small molecule targeting
Online Access:https://www.mdpi.com/2072-6694/15/11/2977

Internet

https://www.mdpi.com/2072-6694/15/11/2977

Similar Items