TRPM8 deficiency attenuates liver fibrosis through S100A9-HNF4α signaling

TRPM8 deficiency attenuates liver fibrosis through S100A9-HNF4α signaling

Abstract Background Liver fibrosis represent a major global health care burden. Data emerging from recent advances suggest TRPM8, a member of the transient receptor potential (TRP) family of ion channels, plays an essential role in various chronic inflammatory diseases. However, its role in liver fi...

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Bibliographic Details
Main Authors: Qiang Liu, Xiaohua Lei, Zhenyu Cao, Ju Zhang, Likun Yan, Jie Fu, Qing Tong, Wei Qin, Yaoli Shao, Chun Liu, Zhiqiang Liu, Zicheng Wang, Yuan Chu, Ge Xu, Siyuan Liu, Xueyi Wen, Hirofumi Yamamoto, Masaki Mori, Xin. M. Liang, Xundi Xu
Format: Article
Language:English
Published: BMC 2022-05-01
Series:Cell & Bioscience
Subjects:
TRPM8
Liver fibrosis
ECM
Inflammation
S100A9
HNF4α
Online Access:https://doi.org/10.1186/s13578-022-00789-4

Internet

https://doi.org/10.1186/s13578-022-00789-4

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