Enhancer promoter interactome and Mendelian randomization identify network of druggable vascular genes in coronary artery disease

Enhancer promoter interactome and Mendelian randomization identify network of druggable vascular genes in coronary artery disease

Abstract Coronary artery disease (CAD) is a multifactorial disorder, which is partly heritable. Herein, we implemented a mapping of CAD-associated candidate genes by using genome-wide enhancer-promoter conformation (H3K27ac-HiChIP) and expression quantitative trait loci (eQTL). Enhancer-promoter anc...

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Bibliographic Details
Main Authors: Arnaud Chignon, Samuel Mathieu, Anne Rufiange, Déborah Argaud, Pierre Voisine, Yohan Bossé, Benoit J. Arsenault, Sébastien Thériault, Patrick Mathieu
Format: Article
Language:English
Published: BMC 2022-03-01
Series:Human Genomics
Subjects:
Atherosclerosis
Coronary artery disease
Genes
3D genome
Mendelian randomization
Druggable genome
Online Access:https://doi.org/10.1186/s40246-022-00381-4

Internet

https://doi.org/10.1186/s40246-022-00381-4

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