Ligand bias underlies differential signaling of multiple FGFs via FGFR1

Ligand bias underlies differential signaling of multiple FGFs via FGFR1

The differential signaling of multiple FGF ligands through a single fibroblast growth factor (FGF) receptor (FGFR) plays an important role in embryonic development. Here, we use quantitative biophysical tools to uncover the mechanism behind differences in FGFR1c signaling in response to FGF4, FGF8,...

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Bibliographic Details
Main Authors: Kelly Karl, Nuala Del Piccolo, Taylor Light, Tanaya Roy, Pooja Deduja, Vlad-Constantin Ursachi, Bohumil Fafilek, Pavel Krejci, Kalina Hristova
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-04-01
Series:eLife
Subjects:
signal transduction
FGFR
biased signaling
Online Access:https://elifesciences.org/articles/88144

Internet

https://elifesciences.org/articles/88144

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