Differential Immune Response to Bioprosthetic Heart Valve Tissues in the α1,3Galactosyltransferase-Knockout Mouse Model

Differential Immune Response to Bioprosthetic Heart Valve Tissues in the α1,3Galactosyltransferase-Knockout Mouse Model

Structural valve deterioration (SVD) of bioprosthetic heart valves (BHVs) has great clinical and economic consequences. Notably, immunity against BHVs plays a major role in SVD, especially when implanted in young and middle-aged patients. However, the complex pathogenesis of SVD remains to be fully...

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Bibliographic Details
Main Authors: Kelly Casós, Roger Llatjós, Arnau Blasco-Lucas, Sebastián G. Kuguel, Fabrizio Sbraga, Cesare Galli, Vered Padler-Karavani, Thierry Le Tourneau, Marta Vadori, Andrea Perota, Jean-Christian Roussel, Tomaso Bottio, Emanuele Cozzi, Jean-Paul Soulillou, Manuel Galiñanes, Rafael Máñez, Cristina Costa
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Bioengineering
Subjects:
bioprosthetic heart valves
structural valve deterioration
α1,3-galactosyltransferase-knockout mice
anti-Gal antibodies
cellular immune infiltrate
Online Access:https://www.mdpi.com/2306-5354/10/7/833

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https://www.mdpi.com/2306-5354/10/7/833

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