17β-estradiol promotes osteogenic differentiation of BMSCs by regulating mitophagy through ARC

17β-estradiol promotes osteogenic differentiation of BMSCs by regulating mitophagy through ARC

Abstract The study aims to elucidate the mechanism through which 17β-estradiol facilitates osteogenic differentiation in bone marrow mesenchymal stem cells (BMSCs). In our study, lentiviral transfection was employed to establish apoptosis repressor with caspase recruitment domain (ARC) knockdown or...

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Bibliographic Details
Main Authors: Jingcun Shi, Jin Wen, Longwei Hu
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
17β-estradiol
ARC
BMSCs
Osteogenic differentiation
Mitophagy
MAPK
Online Access:https://doi.org/10.1186/s13018-024-05400-9

Internet

https://doi.org/10.1186/s13018-024-05400-9

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