Combined anti-angiogenic therapy targeting PDGF and VEGF receptors lowers the interstitial fluid pressure in a murine experimental carcinoma.

Combined anti-angiogenic therapy targeting PDGF and VEGF receptors lowers the interstitial fluid pressure in a murine experimental carcinoma.

Elevation of the interstitial fluid pressure (IFP) of carcinoma is an obstacle in treatment of tumors by chemotherapy and correlates with poor drug uptake. Previous studies have shown that treatment with inhibitors of platelet-derived growth factor (PDGF) or vascular endothelial growth factor (VEGF)...

Full description

Bibliographic Details
Main Authors: Agnieszka Kłosowska-Wardega, Yoko Hasumi, Mikhail Burmakin, Aive Ahgren, Linda Stuhr, Ingrid Moen, Rolf K Reed, Kristofer Rubin, Carina Hellberg, Carl-Henrik Heldin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-12-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2781164?pdf=render

Internet

http://europepmc.org/articles/PMC2781164?pdf=render

Similar Items