Inflammatory Mediators and Gut Microbial Toxins Drive Colon Tumorigenesis by IL-23 Dependent Mechanism

Inflammatory Mediators and Gut Microbial Toxins Drive Colon Tumorigenesis by IL-23 Dependent Mechanism

Obesity-associated chronic inflammation predisposes colon cancer risk development. Interleukin-23 (IL-23) is a potential inflammatory mediator linking obesity to chronic colonic inflammation, altered gut microbiome, and colon carcinogenesis. We aimed to elucidate the role of pro-inflammatory eicosan...

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Bibliographic Details
Main Authors: Janani Panneerselvam, Venkateshwar Madka, Rajani Rai, Katherine T. Morris, Courtney W. Houchen, Parthasarathy Chandrakesan, Chinthalapally V. Rao
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Cancers
Subjects:
colon cancer
IL-23
obesity
inflammation
innate immunity
Online Access:https://www.mdpi.com/2072-6694/13/20/5159

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https://www.mdpi.com/2072-6694/13/20/5159

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