Role of Lung P450 Oxidoreductase in Paraquat-Induced Collagen Deposition in the Lung

Paraquat (PQ) is an agrochemical known to cause pulmonary fibrosis. PQ-induced collagen deposition in the lung is thought to require enzymatic formation of PQ radicals, but the specific enzymes responsible for this bioactivation event in vivo have not been identified. We tested the hypothesis that l...

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Bibliographic Details
Main Authors: Nataliia Kovalchuk, Joseph L. Jilek, Laura S. Van Winkle, Nathan J. Cherrington, Xinxin Ding
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Antioxidants
Subjects:
Online Access:https://www.mdpi.com/2076-3921/11/2/219