Methylation of KRAS by SETD7 promotes KRAS degradation in non-small cell lung cancer

Methylation of KRAS by SETD7 promotes KRAS degradation in non-small cell lung cancer

Summary: Oncogenic KRAS mutations are a key driver for initiation and progression in non-small cell lung cancer (NSCLC). However, how post-translational modifications (PTMs) of KRAS, especially methylation, modify KRAS activity remain largely unclear. Here, we show that SET domain containing histone...

Full description

Bibliographic Details
Main Authors: Cheng-Yao Chiang, Songqing Fan, Hongmei Zheng, Wenjun Guo, Zehan Zheng, Yihua Sun, Chuanqi Zhong, Juan Zeng, Shuaihu Li, Min Zhang, Tian Xiao, Duo Zheng
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Cell Reports
Subjects:
CP: Molecular biology
CP: Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723010148

Internet

http://www.sciencedirect.com/science/article/pii/S2211124723010148

Similar Items