Engineered dual affinity protein fragments to bind collagen and capture growth factors

Engineered dual affinity protein fragments to bind collagen and capture growth factors

Collagen type I lacks affinity for growth factors (GFs) and yet it is clinically used to deliver bone morphogenic protein 2 (BMP-2), a potent osteogenic growth factor. To mitigate this lack of affinity, supra-physiological concentrations of BMP-2 are loaded in collagen sponges leading to uncontrolle...

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Bibliographic Details
Main Authors: Stylianos O. Sarrigiannidis, Oana Dobre, Alexandre Rodrigo Navarro, Matthew J. Dalby, Cristina Gonzalez-Garcia, Manuel Salmeron-Sanchez
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Materials Today Bio
Subjects:
Collagen
Bone regeneration
Recombinant protein fragment
Fibronectin
Biomaterials
Human mesenchymal stem cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006423001011

Internet

http://www.sciencedirect.com/science/article/pii/S2590006423001011

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