Chronic Dosing with Membrane Sealant Poloxamer 188 NF Improves Respiratory Dysfunction in Dystrophic Mdx and Mdx/Utrophin-/- Mice.

Poloxamer 188 NF (national formulary (NF) grade of P-188) improves cardiac muscle function in the mdx mouse and golden retriever muscular dystrophy models. However in vivo effects on skeletal muscle have not been reported. We postulated that P-188 NF might protect diaphragm muscle membranes from con...

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Váldodahkkit: Bruce E Markham, Stace Kernodle, Jean Nemzek, John E Wilkinson, Robert Sigler
Materiálatiipa: Artihkal
Giella:English
Almmustuhtton: Public Library of Science (PLoS) 2015-01-01
Ráidu:PLoS ONE
Liŋkkat:http://europepmc.org/articles/PMC4527695?pdf=render