A flexible dose-response modeling framework based on continuous toxicity outcomes in phase I cancer clinical trials
Abstract Background The past few decades have seen remarkable developments in dose-finding designs for phase I cancer clinical trials. While many of these designs rely on a binary toxicity response, there is an increasing focus on leveraging continuous toxicity responses. A continuous toxicity respo...
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| Format: | Article |
| Language: | English |
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BMC
2023-11-01
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| Series: | Trials |
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| Online Access: | https://doi.org/10.1186/s13063-023-07793-0 |