Two-way communication between SecY and SecA suggests a Brownian ratchet mechanism for protein translocation

Two-way communication between SecY and SecA suggests a Brownian ratchet mechanism for protein translocation

The essential process of protein secretion is achieved by the ubiquitous Sec machinery. In prokaryotes, the drive for translocation comes from ATP hydrolysis by the cytosolic motor-protein SecA, in concert with the proton motive force (PMF). However, the mechanism through which ATP hydrolysis by Sec...

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Bibliographic Details
Main Authors: William John Allen, Robin Adam Corey, Peter Oatley, Richard Barry Sessions, Steve A Baldwin, Sheena E Radford, Roman Tuma, Ian Collinson
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-05-01
Series:eLife
Subjects:
protein secretion
protein translocation
single molecule FRET
molecular dynamics
SecYEG
SecA
Online Access:https://elifesciences.org/articles/15598

Internet

https://elifesciences.org/articles/15598

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