Synthesis of Functionalized Isoquinolone Derivatives via Rh(III)-Catalyzed [4+2]-Annulation of Benzamides with Internal Acetylene-Containing α-CF<sub>3</sub>-α-Amino Carboxylates

Synthesis of Functionalized Isoquinolone Derivatives via Rh(III)-Catalyzed [4+2]-Annulation of Benzamides with Internal Acetylene-Containing α-CF<sub>3</sub>-α-Amino Carboxylates

A convenient pathway to a new series of α-CF<sub>3</sub>-substituted α-amino acid derivatives bearing pharmacophore isoquinolone core in their backbone has been developed. The method is based on [4+2]-annulation of <i>N-</i>(pivaloyloxy) aryl amides with orthogonally protecte...

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Bibliographic Details
Main Authors: Daria V. Vorobyeva, Dmitry A. Petropavlovskikh, Ivan A. Godovikov, Fedor M. Dolgushin, Sergey N. Osipov
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Molecules
Subjects:
acetylenes
amino acids
C-H activation
annulation
catalysis
isoquinolones
Online Access:https://www.mdpi.com/1420-3049/27/23/8488

Internet

https://www.mdpi.com/1420-3049/27/23/8488

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