Genome-wide study of response to platinum, taxane, and combination therapy in ovarian cancer: in vitro phenotypes, inherited variation, and disease recurrence

Genome-wide study of response to platinum, taxane, and combination therapy in ovarian cancer: in vitro phenotypes, inherited variation, and disease recurrence

Abstract:Background: The standard treatment for epithelial ovarian cancer (EOC) patients with advanced disease is carboplatin-paclitaxel combination therapy following initial debulking surgery, yet there is wide inter-patient variation in clinical response. We sought to identify pharmacogenomic mar...

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Bibliographic Details
Main Authors: Brooke L Fridley, Taraswi Mitra Ghosh, Alice eWang, Rama eRaghavan, Junqiang eDai, Ellen L Goode, Jatinder K Lamba
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-03-01
Series:Frontiers in Genetics
Subjects:
Apoptosis
Carboplatin
Paclitaxel
pharmacogenomics
ovarian cancer
genome-wide association
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2016.00037/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fgene.2016.00037/full

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