Implication of Intra-Tumor Heterogeneity on Colorectal Cancer Response to MEK Inhibition
Intra-tumor heterogeneity (ITH) poses a major obstacle in cancer therapy. In colorectal cancer (CRC), mutations in the transforming growth factor-β/bone morphogenetic protein (TGF-β/BMP) pathway, especially in the SMAD4 gene, have been correlated with decreased overall survival and are suspected to...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Biology and Life Sciences Forum |
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| Online Access: | https://www.mdpi.com/2673-9976/21/1/19 |