Wild-type EGFR Is Stabilized by Direct Interaction with HSP90 in Cancer Cells and Tumors

Wild-type EGFR Is Stabilized by Direct Interaction with HSP90 in Cancer Cells and Tumors

The epidermal growth factor receptor (EGFR) has been targeted for inhibition using tyrosine kinase inhibitors and monoclonal antibodies, with improvement in outcome in subsets of patients with head and neck, lung, and colorectal carcinomas. We have previously found that EGFR stability plays a key ro...

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Bibliographic Details
Main Authors: Aarif Ahsan, Susmita G. Ramanand, Christopher Whitehead, Susan M. Hiniker, Alnawaz Rehemtulla, William B. Pratt, Shruti Jolly, Christopher Gouveia, Kristy Truong, Carter Van Waes, Dipankar Ray, Theodore S. Lawrence, Mukesh K. Nyati
Format: Article
Language:English
Published: Elsevier 2012-08-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558612800017

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http://www.sciencedirect.com/science/article/pii/S1476558612800017

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