Inhibition of indoleamine dioxygenase leads to better control of tuberculosis adjunctive to chemotherapy

Inhibition of indoleamine dioxygenase leads to better control of tuberculosis adjunctive to chemotherapy

The expression of indoleamine 2,3-dioxygenase (IDO), a robust immunosuppressant, is significantly induced in macaque tuberculosis (TB) granulomas, where it is expressed on IFN-responsive macrophages and myeloid-derived suppressor cells. IDO expression is also highly induced in human TB granulomas, a...

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Bibliographic Details
Main Authors: Bindu Singh, Chivonne Moodley, Dhiraj K. Singh, Ruby A. Escobedo, Riti Sharan, Garima Arora, Shashank R. Ganatra, Vinay Shivanna, Olga Gonzalez, Shannan Hall-Ursone, Edward J. Dick Jr., Deepak Kaushal, Xavier Alvarez, Smriti Mehra
Format: Article
Language:English
Published: American Society for Clinical investigation 2023-01-01
Series:JCI Insight
Subjects:
Immunology
Infectious disease
Online Access:https://doi.org/10.1172/jci.insight.163101

Internet

https://doi.org/10.1172/jci.insight.163101

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