Andersen–Tawil Syndrome Is Associated With Impaired PIP2 Regulation of the Potassium Channel Kir2.1

Andersen–Tawil Syndrome Is Associated With Impaired PIP2 Regulation of the Potassium Channel Kir2.1

Andersen–Tawil syndrome (ATS) type-1 is associated with loss-of-function mutations in KCNJ2 gene. KCNJ2 encodes the tetrameric inward-rectifier potassium channel Kir2.1, important to the resting phase of the cardiac action potential. Kir-channels’ activity requires interaction with the agonist phosp...

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Bibliographic Details
Main Authors: Reem Handklo-Jamal, Eshcar Meisel, Daniel Yakubovich, Leonid Vysochek, Roy Beinart, Michael Glikson, Julie R. McMullen, Nathan Dascal, Eyal Nof, Shimrit Oz
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Pharmacology
Subjects:
Andersen–Tawil syndrome
cardiac arrhythmia
PIP2
inward-rectifier potassium channel
slide helix
G-loop
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00672/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00672/full

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