Engineered peptide PLG0206 overcomes limitations of a challenging antimicrobial drug class.

Engineered peptide PLG0206 overcomes limitations of a challenging antimicrobial drug class.

The absence of novel antibiotics for drug-resistant and biofilm-associated infections is a global public health crisis. Antimicrobial peptides explored to address this need have encountered significant development challenges associated with size, toxicity, safety profile, and pharmacokinetics. We de...

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Bibliographic Details
Main Authors: David B Huang, Kimberly M Brothers, Jonathan B Mandell, Masashi Taguchi, Peter G Alexander, Dana M Parker, Dean Shinabarger, Chris Pillar, Ian Morrissey, Stephen Hawser, Parviz Ghahramani, Despina Dobbins, Nicholas Pachuda, Ronald Montelaro, Jonathan D Steckbeck, Kenneth L Urish
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0274815

Internet

https://doi.org/10.1371/journal.pone.0274815

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