A serine protease inhibitor camostat mesilate prevents podocyte apoptosis and attenuates podocyte injury in metabolic syndrome model rats

A serine protease inhibitor camostat mesilate prevents podocyte apoptosis and attenuates podocyte injury in metabolic syndrome model rats

Metabolic syndrome (MetS) is associated with chronic kidney disease and proteinuria. Previously, we reported that a synthetic serine protease inhibitor, camostat mesilate (CM), mitigated hypertension and proteinuria in rodent disease models. The present study evaluated the anti-hypertensive and anti...

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Bibliographic Details
Main Authors: Teruhiko Mizumoto, Yutaka Kakizoe, Terumasa Nakagawa, Yasunobu Iwata, Yoshikazu Miyasato, Kohei Uchimura, Masataka Adachi, Qinyuan Deng, Manabu Hayata, Jun Morinaga, Taku Miyoshi, Yuichiro Izumi, Takashige Kuwabara, Yoshiki Sakai, Kimio Tomita, Kenichiro Kitamura, Masashi Mukoyama
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Journal of Pharmacological Sciences
Subjects:
Camostat mesilate
Serine protease
Metabolic syndrome
Podocyte injury
Proteinuria
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861321000360

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http://www.sciencedirect.com/science/article/pii/S1347861321000360

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